The receptor binding domain (RBD) of the SARS-CoV-2 coronavirus 2 spike protein has undergone several mutations since the emergence of the virus in late 2019. Mutations in the SARS-CoV-2 RBD have resulted in several new variants of concern (VOCs) such as the Alpha, Beta, Gamma, and Delta variants and now the Omicron variant, which threaten to mitigate the effect of global vaccination campaigns against SARS-CoV-2. A better understanding of the mechanisms of these SARS-CoV-2 RBD mutations could help predict the emergence of new VOCs and prevent their spread.
Participants in the second study included: Marco Zaccaria, Department of Biology, Boston College, Chestnut Hill MA, United States Luigi Genovese, Université Grenoble Alpes, CEA, IRIG-MEM, L Sim, Grenoble, France Michael Farzan, Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter FL, United States William Dawson, RIKEN Center for Computational Science, Kobe, Japan Takahito Nakajima, RIKEN Center for Computational Science, Kobe, Japan Welkin Johnson, Department of Biology, Boston College, Chestnut Hill MA, United States Babak Momeni, Department of Biology, Boston College, Chestnut Hill MA, United States-
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.