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DNP-enhanced solid-state NMR in Grenoble

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Published on 24 October 2022
Magic Angle Spinning Dynamic Nuclear Polarization & sustainable cryogenic helium sample spinning
DNP-enhanced solid-state NMR in Grenoble

The DNP group in Grenoble (part of the RM team) is specialized in Nuclear Magnetic Resonance (NMR) and is currently actively developing an emerging nuclear hyperpolarizaiton approach called Magic Angle Spinning Dynamic Nuclear Polarizaiton (MAS-DNP). It belongs to MEM Laboratory located at CEA Grenoble, is part of the PFNC, and is supported by CEA and Grenoble-Alpes University.

Current research axes

Fast and cool sample spinning with helium!
We develop both the instrumentation and the methodology to go beyond the current sensitivity limits with the goal to significantly enlarge the scope of solid-state NMR measurements. These developments are used to reach levels of sensitivity and resolution that have never been achieved, in order to tackle highly-relevant chemical and biological questions that can't be solved by X-ray or solution-state NMR. Among the recent important contributions we made, we used MAS-DNP to probe 13C-13C proximities (~hours long experiments) at natural isotopic abundance.This is an important approach for various systems that cannot be easily isotopically enriched and for which X-ray analysis is often not suitable. We also showed that MAS-DNP could be used to answer a decades’ old problem of siloxane condensation networks (using 29Si-29Si proximities) and probe the surface structure of catalytic aluminas (using 27Al-27Al proximities and MQMAS experiments), as well as on bacterial cells. Overall, our systems of interest are rather broad and range from biomolecules and bio-materials to polymers and inorganic systems. These efforts are often combined with other expertize in EPR, DFT, and radical synthesis either through local or (inter)national collaborations.
On the instrumentation side, our effort currently involves a strong collaboration between researchers / engineers / technicians from the MEM and SBT laboratories at Inac to reach sustainable closed-loop cryogenic helium sample spinning. After several years of effort, we have successfully assembled a first-generation cryostat that is currently under testing in the DNP laboratory. The "ultra-low" temperature measurements are conducted on a prototype probe developed by Bruker Biospin.

Major milestones of our research over the last four years, besides the appended highlights can be found here.

Permanent members of the DNP group:

Gaël De Paëpe (personal website, researchgate profile, list of publications)
Sabine Hediger (mendeley profile)
Daniel Lee (personal website, researchgate profile, mendeley profile)
Eric Bouleau
Pierre Dalban-Moreynas

Post-Doctoral Fellows:

Adam Smith
Diego Gauto

PhD Students:
Natalia Olejnik-Fehér
Saumya Badoni
Akshay Kumar
Rania Harrabi

Former members:
Ildefonso Marin-Montesinos
Katharina Märker
Sachin Chaudhari
Frédéric Mentink-Vigier
Nghia Tuan Duong
Subhradip Paul
Carlos Fernadez
Hiroki Takahashi
Monu Kaushik
Bastien Viverge
Alexis Ponchon
Lucian Caliap
Myriam Chanal
Lida Esfandiary

Funding Agency:
Agence Nationale pour la Recherche
FP7 Marie Curie Actions

Agence Nationale de la Recherche
European Research Council

PFNC - Center for nanoscale characterization

Les dossiers vidéos de la Plateforme de Nanocaractérisation PFNC @ Minatec

L’avenir de la microscopie
Amal Chabli, chercheur (CEA - Minatec) 19/05/2008

Le spectromicroscope de photo-électrons XPEEM
Olivier Renault, Ingénieur (CEA/Minatec) 19/05/2008

Le ToFSIMS Analyste de haut vol
Jean-Paul Barnes, Ingénieur-Chercheur (CEA/Minatec) 19/05/2008

Le microscope à force atomique
Nicolas Chevalier, Ingénieur en microscopie en champ proche (CEA/Minatec) 19/05/2008

Le microscope électronique à balayage
Pierre-Henri Jouneau, Ingénieur (CEA/Minatec) 19/05/2008

Plate-forme de nanocaractérisation du CEA/Grenoble
Amal Chabli, chercheur (CEA/Minatec) 19/05/2008